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Dr Jamil Jubrail, Lecturer

Dr Jamil Jubrail PhD

Lecturer

Faculty of Sport, Health and Social Sciences

Biography

Jamil graduated with a master’s degree in Biochemistry and Microbiology from the University of Sheffield in 2010.

In 2014 he was awarded his PhD from the University of Sheffield where he identified how Staphylococcus aureus hijacked human macrophages in order to survive and spread to distant sites. Following this he moved to the Institut Cochin in Paris to undertake post-doctoral research, in collaboration with AstraZeneca, exploring how rhinovirus perturbed airway macrophage functions preventing their ability to control secondary bacterial infection. Dr Jubrail described new mechanisms used by rhinovirus to disrupt macrophage functions and identified for the first time key proteins targeted by the virus to affect the cell’s functions. He also implicated new cellular functions for these proteins.

He then moved to the University of Edinburgh to carry out further post-doctoral training, where he evaluated the therapeutic potential of host defence peptides and different inducers of these peptides during respiratory syncytial virus (RSV) infection of human epithelial cells.

In 2021 Jamil moved to Solent University to begin a new lectureship position and establish his own research group. He is also an active member within respiratory societies including the European Respiratory Society (ERS) and serves as a reviewer for the European Board for Accreditation in Pneumology (EBAP) as well as a peer reviewer for numerous journals and societies.

Taught courses

Further information

Recent publications

2020

Best A*, Jubrail J*, Boots M, Dockrell D, Marriott H (A mathematical model shows macrophages delay Staphylococcus aureus replication, but limitations in microbicidal capacity restrict bacterial clearance) Journal of Theoretical Biology, 2020, July 497: 110256 *joint first authorship

Jubrail J, Africano-Gomez K, Herit F, Mularski A, Bourdoncle P, Oberg L, Israelsson E, Burgel PR, Mayer G, Cunoosamy D, Kurian N, Niedergang F (Arpin is critical for phagocytosis in macrophages and is targeted by human rhinovirus). EMBO reports, 2020, Jan 21(1): e47963

2019

Preston JA, Bewley MA, Marriott HM, McGarry Houghton A, Mohasin M, Jubrail J, Morris L, Stephenson YL, Cross S, Greaves DR, Craig RW, van Rooijen N, Bingle CD, Read RC, Mitchell TJ, Whyte MKB, Shapiro SD, Dockrell DH (Alveolar Macrophage Apoptosis-Associated Bacterial Killing Helps Prevent Murine Pneumonia). American journal of respiratory and critical care medicine, 2019, July 200(1): 84-97

2018

Jubrail J, Africano-Gomez K, Herit F, Baturcam E, Mayer G, Cunoosamy DM, Kurian N, Niedergang F (HRV16 Impairs Macrophages Cytokine Response to a Secondary Bacterial Trigger). Frontiers in immunology, 2018, December 9: 2908

2017

Jubrail J, Kurian N, Niedergang F (Macrophage phagocytosis cracking the defect code in COPD). Biomedical journal, 2017, December 40(6): 305-312

Almendros I, Bartel S, Bostantzoglou C, Jubrail J, Lehmann M, Wagner D (Early Career Members at the ERS LSC 2017: mechanistic overlap between chronic lung injury and cancer). Breathe (Sheffield, England), 2017, December 13(4): 323-326 All authors had equal authorship.

2016

Jubrail J, Morris P, Bewley MA, Stoneham S, Johnston SA, Foster SJ, Peden AA, Read RC, Marriott HM, Dockrell DH (Inability to sustain intraphagolysosomal killing of Staphylococcus aureus predisposes to bacterial persistence in macrophages).Cellular microbiology, 2016, Jan 18(1): 80-96

2014

Cole J, Aberdein J, Jubrail J, Dockrell DH (The role of macrophages in the innate immune response to Streptococcus pneumoniae and Staphylococcus aureus: mechanisms and contrasts). Advances in microbial physiology, 2014, November, 65: 125-202

Teaching experience

Jamil has supervised a range of BSc and MSc students during his PhD and post-doctoral positions and recently began PhD supervision. He has taught immunology, microbiology and cell biology at undergraduate level and immunology and microbiology at postgraduate level. Jamil specialises in immunology and medical microbiology and has experience of teaching a broad curriculum within these areas.

Awards

  • Young Scientist Scholarship (European Respiratory Society) 2017.
  • Post-Doctoral Oral Presentation Award (British Association for Lung Research) 2018.
  • Two early career scientist grants in 2016 and 2017.
  • Poster presentation Award Sheffield 2013.
  • Presentation Award Bacterial Conference 2011.
  • BBSRC Undergraduate Funding Scholarship 2008.

Research interests

Jamil’s research interests centre on host: pathogen interactions in conditions of chronic inflammation. He is particularly interested in how respiratory viruses disrupt the ability of airway epithelial cells and macrophages to respond to secondary targets and maintain tissue homeostasis. He uses a range of in vitro and human cellular models to study these interactions. His research has four key aims:

  1. to identify new cellular targets required for viral infection and to characterise their function,
  2. to understand how viruses hijack these proteins to disrupt cellular functions leading to increased infection and viral spread,
  3. to determine if these proteins are modified by inflammation, and
  4. to translate these findings into new treatments for patients with inflammatory airway conditions exacerbated by these viruses.

Jamil believes that by knowing what proteins a virus needs to survive within cells and ultimately spread could lead to the development of new and specific therapies to prevent patients with underlying inflammatory conditions from suffering ongoing exacerbations.

The Jubrail lab is currently accepting applications from self-motivated PhD students and post-doctoral researchers. Please email jamil.jubrail@solent.ac.uk in the first instance to discuss potential projects.