Willoughby JE, Kerr JP, Rogel A, Taraban VY, Buchan SL, Johnson PW, AlShamkhani A. 2014. Differential impact of CD27 and 4-1BB costimulation on effector and memory CD8 T cell generation following peptide immunization. J Immunol. 193(1):244-51.
Taraban VY, Rowley TF, Kerr JP, Willoughby JE, Johnson PM, Al-Shamkhani A, Buchan SL. CD27 costimulation contributes substantially to the expansion of functional memory CD8(+) T cells after peptide immunization. Eur J Immunol. 2013, 43(12):3314-23.
Polak, M.E., L. Newell, V.Y. Taraban, C. Pickard, E. Healy, P.S. Friedmann, A. AlShamkhani, and M.R. Ardern-Jones. 2012. CD70-CD27 interaction augments CD8+ T-cell activation by human epidermal Langerhans cells. J Invest Dermatol 132:1636- 1644.
Vadim’s research interests include mechanisms of lymphocyte activation and of the regulation of T-cell functions through co-stimulatory receptors of the tumour necrosis factor receptor (TNFR) superfamily, with particular emphasis on muscular-skeletal, intestinal and skin inflammation.
Recent research themes have also included low grade inflammation in metabolic disorders and inflammatory responses in muscular damage (exercise-associated muscular straining). In particular focus is the role of mammalian and human polynucleotide phosphorylase (PNPase/PNPT1) in regulation of lymphocyte activation and the pathogenesis of the chronic lymphocytic leukaemia.
While the main focus of his teaching interests is immunology and cell biology, Vadim has a considerable experience of teaching a broad bioscience curriculum for undergraduate students through levels 4 to 6, as well as of supervising research projects of final-year BSc and PhD students.